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李楠

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工作照


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李楠2009年参加澳大利亚免疫学年会


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指导学生



联系方式:

电话:13020102127

邮箱:linan@immunol.org

 

个人简介:

女,博士,教授。1996年毕业于南开大学生命科学学院,获理学学士学位;2002年毕业于第二军医大学免疫学教研室,获医学博士学位; 2002-2004年任第二军医大学基础部免疫学教研室讲师;2004-2008年任第二军医大学基础部免疫学教研室副教授;2008.9任第二军医大学基础部免疫学教研室教授。2015.3-2016.3于加拿大玛格丽特公主医院Campbell乳腺癌研究所Tak Mak实验室从事访问学者研究。长期从事分子免疫学研究。在J Exp Med、Cancer Res、J Biol Chem、J Immunol、Sci RepClin Cancer Res等期刊发表多篇论文。作为负责人承担国家“新药创制”科技重大专项,973计划课题、863计划专题课题、上海市重大科技项目等重大课题。

 

研究方向及主要发现:

1)新型免疫分子的发现及功能研究;

(2)基于新分子的药物靶标和免疫治疗靶标研发的应用基础研究

 

获奖情况:

2003年国家自然科学奖二等奖(第5完成人),2006年中华医学科技奖一等奖(第2完成人),2015年上海市自然科学奖一等奖(第2完成人),博士毕业论文被评为2004年全国百篇优秀博士学位论文, 2005年教育部“新世纪优秀人才”,2011年中国科协杰出青年奖(实用工程奖),2010年度第十一届中国青年科技奖,上海市三八红旗手

 

代表性论文论著:

1. Sun W, Shi J, Wu J, Zhang J, Chen H, Li Y, Liu S, Wu Y, Tian Z, Cao X, Li N. A modified HLA-A*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses. Cell Mol Immunol. 2018 Jan 29. doi: 10.1038/cmi.2017.155. [Epub ahead of print] PubMed PMID: 29375131.

2. Wang C, Wang Q, Xu X, Xie B, Zhao Y, *Li N, Cao X. The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3. J Exp Med. 2017 Dec 4;214(12):3597-3610. doi: 10.1084/jem.20170856. Epub 2017 Nov 3(*co-correspondence)

3. Ren W, Wang C, Wang Q, Zhao D, Zhao K, Sun D, Liu X, Han C, Hou J, Li X, Zhang Q, Cao X, Li N. Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. Sci Rep. 2017 Jan 3;7:39986. doi: 10.1038/srep39986. 

4. Li N, Zheng Y, Chen W, Wang C, Liu X, He W, Xu H, Cao X.Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res. 2007 Dec 1;67(23):11176-85.

5. *Li N, Wang C, Wu Y, Liu X, Cao X. Ca(2+)/calmodulin-dependent protein kinase II promotes cell cycle progression by directly activating MEK1 and subsequently modulating p27 phosphorylation. J Biol Chem. 2009 Jan 30;284(5):3021-7. (*co-correspondence) 

6. Li N, Zhang W, Wan T, Zhang J, Chen T, Yu Y, Wang J, Cao X. Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells. J Biol Chem. 2001 Jul 27;276(30):28106-12. 

7. Wang C, Liu X, Liu Y, Zhang Q, Yao Z, Huang B, Zhang P, *Li N, Cao X. ZFP64 promotes TLR-triggered pro-inflammatory and type I interferon production in macrophages by enhancing p65 activation. J Biol Chem. 2013 Aug 23;288(34):24600-8. (*co-correspondence)

8. Zhang Q, Wang C, Liu Z, Liu X, Han C, Cao X, Li N. Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting  extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation. J Biol Chem. 2012 Feb 24;287(9):6208-17. 

9. *Wu Y, *Zhu X, *Li N, Chen T, Yang M, Yao M, Liu X, Jin B, Wang X, Cao X. CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination. J Immunol. 2011 Nov 1;187(9):4881-9.* equally contributed

10. *Liu H, *Qiu J, *Li N, Chen T, Cao X. Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha(ERa) in human cancer cells by inhibiting proteasome-dependent ERa degradation via association with Src. J Biol Chem. 2010 Jul 16;285(29):21934-42 *equal contribution)(* equally contributed

11. *Wang C, *Li N, Liu X, Zheng Y, Cao X.A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J Biol Chem. 2008 Apr 25;283(17):11565-74. *equally contributed

12. *Wang X, *Li N, Li H, Liu B, Qiu J, Chen T, Cao X. Silencing of human phosphatidylethanolamine-binding protein 4 sensitizes breast cancer cells to TNFα-induced apoptosis and cell growth arrest. Clin Cancer Res. 2005 Oct 15;11(20):7545-53 *equally contributed

13. *Yang L, *Li N, Wang C, Yu Y, Yuan L, Zhang M, Cao X. Cyclin L2, a novel RNA-polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. J Biol Chem. 2004 Mar 19; 279 (12): 11639-48. * equally contributed

14. *Wang  X, *Li N, Liu B, Sun H, Chen T, Li H, Qiu J, Zhang L, Wan T, Cao X. A novel human phosphatidylethanolamine-binding protein resists TNFα-induced apoptosis by inhibiting MAPK pathway activation and PE externalization. J Biol Chem. 2004 Oct 29; 279(44): 45855-45864. * equally contributed

15. *Wang T, *Xia D, *Li N, Wang C, Chen T, Wan T, Chen G, Cao X. Bone marrow stromal cell-derived growth inhibitor, BDGI, inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis. J Biol Chem. 2005 Feb 11;280(6):4374-82. * equally contributed

16. *Li H, *Wang X, *Li N, Qiu J, Zhang Y, Cao X. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. J Biol Chem. 2007 Feb 16;282(7):4943-50 * equally contributed

17. *Li C, *Liu Q, *Li N, Chen W, Wang L, Wang Y, Yu Y, Cao X.EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway. J Mol Med. 2008 Apr;86(4):471-484* equally contributed

18. Li N, Huang X, Zhao Z, Chen G, Zhang W, Cao X. Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells. Biochem Biophys Res Commun 2000; 279 (2): 487-93.

19. Li N, Zhang W, Cao X. Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett 2000 Nov 1; 74 (3): 221-4.

20. *Sun H, *Li N, Wang X, Liu S, Chen T, Zhang L, Wan T, Cao X. Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells. Biochem Biophys Res Commun 2003 Jan 31;301(1):176-82. *equally contributed

21. *Sun H, *Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan T, Cao X. Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells. Mol Cell Biochem 2005 Jan;269(1-2):85-94. * equally contributed

22. *Sui L, *Li N, Zhang W, Chen Y, Zheng Y, Wan T, Zhang W, Yang Y, Fang G, Mao J, Cao X. Human membrane protein Tim-3 facilitates hepatitis A virus entry into target cells. Int J Mol Med 2006 ; 17(6): 1093-1097*equal contribution

23. *Zhang J, *Li N, Yu J, Zhang W, Cao X. Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells. Biochem Biophys Res Commun 2001 Jul 13; 285(2): 229-34. * equally contributed

24. *Wang Q, *Li N, Wang X, Shen J, Hong X, Yu H, Zhang Y, Wan T, Zhang L, Wang J, Cao X. Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Life Sci. 2007 Jan 9;80(5):420-9 *equally contributed

 

专利:

1. 李楠,曹雪涛,裘建明,一种靶向于人磷脂酰乙醇胺结合蛋白4的抗肿瘤小分子化合物。 国家发明专利号: ZL200910046551.0 授权日期:2014.05.28 

2. 李楠曹雪涛,孙伟红,一种新的hPEBP4蛋白来源的HLA-A2限制性表位多肽及其应用。 国家发明专利号:ZL200910046614.2 授权公告日:2013.11.20

3. 李楠,孙伟红,陈涛涌,曹雪涛,一种新的候选癌基因hRabJ来源的HLA-A2限制性表位多肽及其应用。国家发明专利号:ZL 200510030529.9  授权公告日:2010.12.29

4. 李楠,孙伟红,王晓健,曹雪涛一种新的hPEBP4蛋白来源的HLA-A2限制性表位多肽的发现及其应用国家发明专利号:ZL200510030532.0  授权公告日:2010.9.22

5. 李楠,王春梅,万涛,曹雪涛,人钙离子/钙调蛋白依赖性蛋白激酶II抑制性蛋白a,其编码序列及用途。国家发明专利号:ZL03151428.6授权公告日:2008.08.06

6. 李楠,曹雪涛,刘书逊,林乃松,新型人补体C1r样丝氨酸蛋白酶类似物,其编码序列及用途,国家发明专利号:ZL 200410025742.6  授权公告日:2007.03.14

7. 李楠,章卫平,张君,人钙离子/钙调蛋白依赖性蛋白激酶Ⅱ抑制性蛋白及用途。国家发明专利号:ZL 01113357.0授权公告日:2005.10.19

8. 李楠,章卫平,曹雪涛,人唾液酸结合性免疫球蛋白样凝集素,其编码序列及用途。国家发明专利号:ZL01105501.4  授权公告日:2005.07.27